abstract：:Klebsiella pneumoniae is an important human pathogen, able to accumulate and disseminate a variety of antimicrobial resistance genes. Resistance to colistin, one of the last therapeutic options for multi-drug-resistant bacteria, has been reported increasingly. Colistin-resistant K. pneumoniae (ColRKp) emerged in two h...

journal_title：International journal of antimicrobial agents

authors： Longo LGA,de Sousa VS,Kraychete GB,Justo-da-Silva LH,Rocha JA,Superti SV,Bonelli RR,Martins IS,Moreira BM

更新日期：2019-11-01 00:00:00

abstract：:Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, development of drug resistance increases the risk of treatment failure, disease progression and mortal...

journal_title：International journal of antimicrobial agents

authors： Yang LL,Li Q,Zhou LB,Chen SQ

更新日期：2019-11-01 00:00:00

abstract：:Carbapenemase-producing Enterobacteriaceae (CPE) are emerging multidrug-resistant bacteria responsible for invasive infections, including prosthetic joint infections (PJIs). Local administration of colistin may provide bactericidal concentrations in situ. This study evaluated the efficacy of a colistin-impregnated cem...

journal_title：International journal of antimicrobial agents

authors： Gatin L,Mghir AS,Mouton W,Laurent F,Ghout I,Rioux-Leclercq N,Tattevin P,Verdier MC,Cremieux AC

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Infective endocarditis (IE) is a severe infection, and a leading cause of mortality and morbidity. Due to its favourable microbiological and pharmacological characteristics, daptomycin is routinely used in clinical practice for treating IE. METHODS:A prospective study was conducted at a large tertiary-care hos...

journal_title：International journal of antimicrobial agents

authors： Russo A,Peghin M,Givone F,Ingani M,Graziano E,Bassetti M

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Mixed hepatitis C virus (HCV) genotype (GT) infections are clinically important as different genotypes have varied sensitivities to direct-acting antivirals (DAAs). A high prevalence of mixed GT infections was observed in individuals who inject drugs and had multiple HCV exposures. The prevalence of mixed ...

journal_title：International journal of antimicrobial agents

authors： Nguyen T,Delaugerre C,Valantin MA,Amiel C,Netzer E,L'Yavanc T,Ohayon M,Israel G,Valin N,Day N,Kreplak G,Pialoux G,Calvez V,Molina JM,Marcelin AG,Todesco E

更新日期：2019-10-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA), is an important aetiological cause of community-acquired pneumonia (CAP) and associated with significant morbidity and mortality. Empiric therapy for CAP frequently consists of β-lactam monotherapy or β-lactam/macrolide combination th...

journal_title：International journal of antimicrobial agents

authors： Welte T,Kantecki M,Stone GG,Hammond J

更新日期：2019-10-01 00:00:00

abstract：:Given emerging uropathogen resistance to more recent antibiotics, old antibiotics used for uncomplicated urinary tract infection (UTI) warrant re-examination. In this study, the urinary antibacterial activities of fosfomycin and nitrofurantoin were investigated by determining the urinary inhibitory titre and urinary b...

journal_title：International journal of antimicrobial agents

authors： Wijma RA,Huttner A,van Dun S,Kloezen W,Abbott IJ,Muller AE,Koch BCP,Mouton JW

更新日期：2019-10-01 00:00:00

abstract：:Candida auris (C. auris) is an emerging fungal pathogen causing invasive infections and outbreaks that have been difficult to control in healthcare facilities worldwide. There is a lack of current evidence for pragmatic infection prevention and control recommendations. The aim of this paper was to review the epidemiol...

journal_title：International journal of antimicrobial agents

authors： Kenters N,Kiernan M,Chowdhary A,Denning DW,Pemán J,Saris K,Schelenz S,Tartari E,Widmer A,Meis JF,Voss A

更新日期：2019-10-01 00:00:00

abstract：:In vitro and clinical data were analysed to evaluate the susceptibility profile of itraconazole in light of the new cut-off points. The in vitro activity of itraconazole was compared with that of eight comparators against 119 Candida bloodstream isolates from 2015 to 2018. Minimum inhibitory concentrations (MICs) were...

journal_title：International journal of antimicrobial agents

authors： Giamarellos-Bourboulis EJ,Stamou A,Maraki S,Solomonidi N,Belesiotou E,Pistiki A,Antoniadou E,Vlachogianni G,Mandragos K,Tasioudis C,Katsenos C,Routsi C,Samonis G,Dimopoulos G

更新日期：2019-10-01 00:00:00

abstract：:Little is known about undergraduate education on antibiotic prescribing in Europe and even less about the antibiotic prescribing skills of nearly-graduated medical students. This study aimed to evaluate the antibiotic prescribing skills of final-year medical students across Europe and the education they received durin...

journal_title：International journal of antimicrobial agents

authors： van der Voort T,Brinkman DJ,Benemei S,Böttiger Y,Chamontin B,Christiaens T,Likic R,Mačiulaitis R,Marandi T,Monteiro EC,Papaioannidou P,Pers YM,Pontes C,Raskovic A,Regenthal R,Sanz EJ,Wilson K,Tichelaar J,van Agtmael M

更新日期：2019-09-01 00:00:00

abstract：:Orthopaedic implant-associated infections are a devastating complication of orthopaedic surgery with a significant impact on patients and healthcare systems. The aims of this work were to describe the patterns of antimicrobial resistance, pathogenicity and virulence of clinical bacterial isolates from orthopaedic impl...

journal_title：International journal of antimicrobial agents

authors： Barros J,Melo LDR,Poeta P,Igrejas G,Ferraz MP,Azeredo J,Monteiro FJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Tuberculosis (TB) causes 25% of all deaths among individuals infected with human immunodeficiency virus (HIV). Rifampicin (RIF) is a potent inducer of drug metabolizing enzymes and drug transporters, and co-administration with dolutegravir (DTG) reduces DTG exposure; this can be overcome by doubling the DTG ...

journal_title：International journal of antimicrobial agents

authors： Wang X,Cerrone M,Ferretti F,Castrillo N,Maartens G,McClure M,Boffito M

更新日期：2019-08-01 00:00:00

abstract：:Gram-negative bacterial pathogens are intrinsically resistant to several antibiotics that are not able to penetrate the cell envelope barrier. The aim of this study was to identify peptides that at low concentrations induce susceptibility to these antibiotics in multidrug-resistant (MDR) Gram-negative bacterial strain...

journal_title：International journal of antimicrobial agents

authors： Baker KR,Jana B,Hansen AM,Vissing KJ,Nielsen HM,Franzyk H,Guardabassi L

更新日期：2019-06-01 00:00:00

abstract：:Chlorhexidine is widely used as a disinfectant in hospitals, which may impose a selective pressure on bacteria. This study aimed to determine whether continuous exposure to chlorhexidine could lead to adaptive resistance and cross-resistance as well as investigating potential resistance mechanisms. Three clinical Kleb...

journal_title：International journal of antimicrobial agents

authors： Zhang Y,Zhao Y,Xu C,Zhang X,Li J,Dong G,Cao J,Zhou T

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:This study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii). METHODS AND RESULTS:The isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the interna...

journal_title：International journal of antimicrobial agents

authors： Potron A,Bour M,Triponney P,Muller J,Koebel C,A Bonnin R,Plésiat P

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Overprescribing antibiotics for patients with no bacterial infection is of growing global concern. It is important for timely Antimicrobial Stewardship Program (ASP) intervention to discontinue antibiotics for patients whose symptoms can be explained by non-infective causes, and without availability of bacte...

journal_title：International journal of antimicrobial agents

authors： Loo LW,Liew YX,Lee W,Lee LW,Chlebicki P,Kwa AL

更新日期：2019-05-01 00:00:00

abstract：:Acinetobacter baumannii is an opportunistic pathogen predominantly associated with nosocomial infections. The World Health Organization's data on antibiotic-resistant 'priority pathogens' reports carbapenem-resistant A. baumannii as a pathogen which is in critical need of research and development of new antimicrobials...

journal_title：International journal of antimicrobial agents

authors： Thomas VM,Brown RM,Ashcraft DS,Pankey GA

更新日期：2019-05-01 00:00:00

abstract：:Integrons recruit resistance genes through integrase-driven recombination events that are regulated by the bacterial SOS response and require the repressor LexA. Class 1 integrons genes are expressed from a common promoter, Pc, of which at least 5 predominant variants, classified from weak to strong, have been describ...

journal_title：International journal of antimicrobial agents

authors： Couvé-Deacon E,Jové T,Afouda P,Barraud O,Tilloy V,Scaon E,Hervé B,Burucoa C,Kempf M,Marcos JY,Ploy MC,Garnier F

更新日期：2019-04-01 00:00:00

abstract：:This study investigated the prevalence of doravirine (DOR) resistance mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced patients. DOR resistance was assessed in samples from NNRTI-experienced patients who underwent genotypic testing for virological failure from the Antiretroviral Response...

journal_title：International journal of antimicrobial agents

authors： Sterrantino G,Borghi V,Callegaro AP,Bruzzone B,Saladini F,Maggiolo F,Maffongelli G,Andreoni M,De Gennaro M,Gianotti N,Bagnarelli P,Vergori A,Antinori A,Zazzi M,Zaccarelli M,ARCA Study Group.

更新日期：2019-04-01 00:00:00

abstract：:We have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration-time curve (0-24 h) divided by the minimum inhibitory concentration (AUC24/MIC) is...

journal_title：International journal of antimicrobial agents

authors： Drennan PG,Begg EJ,Gardiner SJ,Kirkpatrick CMJ,Chambers ST

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:There has been recent renewed interest in historical antibiotics because of the increased antibiotic-resistant bacterial strains. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of infections in newborns; however, it is still used off...

journal_title：International journal of antimicrobial agents

authors： Qi H,Kou C,Qi YJ,Tang BH,Wu YE,Jin F,Luo XJ,Shen YH,Guo YJ,Qi X,Wang YC,Dong Q,Chen XK,Shi HY,Zheng Y,Zhao W,Shen AD

更新日期：2019-03-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) bloodstream infections (BSIs) are related to high mortality rates, and combination therapy has been associated with lower mortality in patients treated mostly with colistin. There is a paucity of studies addressing polymyxin B (PMB) treatment for KPC...

journal_title：International journal of antimicrobial agents

authors： Medeiros GS,Rigatto MH,Falci DR,Zavascki AP

更新日期：2019-02-01 00:00:00

abstract：:This study aimed to evaluate the effectiveness and safety of teicoplanin for treating enterococcal infective endocarditis (EIE). A retrospective analysis of a prospective cohort of definite EIE patients treated with teicoplanin in a Spanish referral centre (2000-2017) was performed. The primary outcome was mortality d...

journal_title：International journal of antimicrobial agents

authors： Escolà-Vergé L,Fernández-Hidalgo N,Rodríguez-Pardo D,Pigrau C,González-López JJ,Bartolomé R,Almirante B

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital. METHODS:A total of 141 S. pneumoniae strains isolated between 2009-2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility t...

journal_title：International journal of antimicrobial agents

authors： Midouni B,Mehiri E,Ghariani A,Draoui H,Essalah L,Bouzouita I,Raoult D,Slim-Saidi L,Fournier PE

更新日期：2019-01-01 00:00:00

abstract：:Molecular epidemiology studies aiming at understanding the acquisition of antimicrobial resistance by clinical isolates of Klebsiella pneumoniae are regularly published; however, information on the genes that contribute to its characteristic phenotype of resistance to antibiotics (intrinsic resistome) is scarce. To fi...

journal_title：International journal of antimicrobial agents

authors： Bernardini A,Cuesta T,Tomás A,Bengoechea JA,Martínez JL,Sánchez MB

更新日期：2019-01-01 00:00:00

abstract：:Candida auris is an emerging multidrug-resistant pathogen implicated in numerous outbreaks worldwide, with a notably high mortality rate (ca. 60%). A significant challenge with treatment of these infections is the resistance of C. auris to most antifungal drugs used clinically. Thus, finding co-drugs capable of overco...

journal_title：International journal of antimicrobial agents

authors： Eldesouky HE,Li X,Abutaleb NS,Mohammad H,Seleem MN

更新日期：2018-12-01 00:00:00

abstract：:Candida spp., especially Candida albicans, is one of the main colonisers of the oral cavity. Due to its ability to form biofilms, it can be implicated in dental caries, periodontal disease and denture stomatitis. Microbial cells in biofilms are minimally impacted by conventional drugs. The aim of this study was to fin...

journal_title：International journal of antimicrobial agents

authors： Dutreix L,Bernard C,Juin C,Imbert C,Girardot M

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Fluoroquinolones (FQs) are second-line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, the choice of antimicrobial should be based on both the benefits and adverse effects. This systematic review quantifies the occurrence of common adverse events (AEs) related to FQs in relatio...

journal_title：International journal of antimicrobial agents

authors： Tandan M,Cormican M,Vellinga A

更新日期：2018-11-01 00:00:00

abstract：:Antimicrobial stewardship (AMS) is the cornerstone activity in the combat against antimicrobial resistance. In order to ensure sustainable deployment and development of AMS, a strategic and regulatory framework needs to be provided by national healthcare authorities. Experts from 32 European countries, Israel and Turk...

journal_title：International journal of antimicrobial agents

authors： Beović B,Pulcini C,Dumartin C,Béraud G,Nerat B,Maurel C,Doušak M,Čižman M,LEASH Study Group on behalf of ESCMID Study Group for Antimicrobial StewardshiP (ESGAP).

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The global spread of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) has become a massive threat to human health. We investigated the clonal relatedness of CR-Kp strains in central Taiwan. METHODS:CR-Kp strains were prospectively collected from inpatients referred to Chung Shan Medical University Hospita...

journal_title：International journal of antimicrobial agents

authors： Lu MC,Tang HL,Chiou CS,Wang YC,Chiang MK,Lai YC

更新日期：2018-11-01 00:00:00

abstract：:Management of micro-organisms harbouring AmpC β-lactamases remains challenging. Carbapenems are often considered first-line agents. Due to growing concern regarding carbapenem-resistant Enterobacteriaceae, integrating non-carbapenem treatment strategies is being explored for these pathogens. The primary objective of t...

journal_title：International journal of antimicrobial agents

authors： McKamey L,Venugopalan V,Cherabuddi K,Borgert S,Voils S,Shah K,Klinker KP

更新日期：2018-11-01 00:00:00

abstract：:Data on the efficacy and safety of ceftazidime/avibactam (CAZ-AVI) are limited. A systematic review and meta-analysis was conducted to clarify the role of CAZ-AVI for patients with serious Gram-negative bacterial infections. The PubMed, EMBASE and Cochrane Library databases were searched for randomised controlled tria...

journal_title：International journal of antimicrobial agents

authors： Zhong H,Zhao XY,Zhang ZL,Gu ZC,Zhang C,Gao Y,Cui M

更新日期：2018-10-01 00:00:00

abstract：:Febrile neutropenia (FN) is associated with substantial morbidity and necessitates empirical broad-spectrum antimicrobial treatment. In this prospective cohort study, a risk-guided management strategy for FN using empirical piperacillin/tazobactam (TZP) or a carbapenem was evaluated. The analysis involved 723 FN episo...

journal_title：International journal of antimicrobial agents

authors： Khoo AL,Zhao YJ,Teng M,Ying D,Jin J,Chee YL,Poon LM,Lim SE,Koh LP,Chng WJ,Lim BP,Hsu LY,Chai LYA

更新日期：2018-09-01 00:00:00

abstract：:Carbapenem-resistant Enterobacteriaceae (CRE) are among the most difficult to treat emerging multidrug-resistant organisms. Major limitations exist in surveillance needed to address CRE, particularly in areas with inadequate resources. We utilised optimised strategies to search for data on carbapenem susceptibility of...

journal_title：International journal of antimicrobial agents

authors： Mitgang EA,Hartley DM,Malchione MD,Koch M,Goodman JL

更新日期：2018-09-01 00:00:00

abstract：:The occurrence of vancomycin-resistant Enterococcus faecium (VREfm) in food is relevant to public health as foodborne VREfm may colonize the gut of consumers and transfer vancomycin resistance genes to the indigenous gut microbiota. Therefore, we determined occurrence and elucidated genetic traits of VREfm in Danish r...

journal_title：International journal of antimicrobial agents

authors： Leinweber H,Alotaibi SMI,Overballe-Petersen S,Hansen F,Hasman H,Bortolaia V,Hammerum AM,Ingmer H

更新日期：2018-08-01 00:00:00

abstract：:Multidrug-resistant Acinetobacter baumannii (MDR-Ab) is one of the most significant nosocomial pathogens that is being increasingly isolated in healthcare settings worldwide. Owing to its inherent drug-resistant nature, coupled with its ability to readily acquire resistance to other antibiotic classes, there is a real...

journal_title：International journal of antimicrobial agents

authors： Shukla M,Soni I,Matsuyama K,Tran T,Tanga M,Gong L,Chopra S

更新日期：2018-07-01 00:00:00

abstract：:In this study, the activity of 18 non-carbapenem antibiotics was evaluated against 100 extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-Ec) and 50 ESBL-producing Klebsiella pneumoniae (ESBL-Kp) isolated from urinary tract infections and bacteraemia in 2016. Minimum inhibitory concentrations (MICs)...

journal_title：International journal of antimicrobial agents

authors： Bouxom H,Fournier D,Bouiller K,Hocquet D,Bertrand X

更新日期：2018-07-01 00:00:00

abstract：:The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilut...

journal_title：International journal of antimicrobial agents

authors： Venturini TP,Al-Hatmi AMS,Rossato L,Azevedo MI,Keller JT,Weiblen C,Santurio JM,Alves SH

更新日期：2018-05-01 00:00:00

abstract：:Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira strains isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatmen...

journal_title：International journal of antimicrobial agents

authors： Liegeon G,Delory T,Picardeau M

更新日期：2018-05-01 00:00:00

abstract：:The molecular mechanisms and characteristics of rifampicin (RIF) resistance in Staphylococcus epidermidis are poorly characterised, even though S. epidermidis is one of the most common nosocomial pathogens associated with indwelling medical device-related infections. The aim of this study was to investigate the evolut...

journal_title：International journal of antimicrobial agents

authors： Wi YM,Greenwood-Quaintance KE,Brinkman CL,Lee JYH,Howden BP,Patel R

更新日期：2018-05-01 00:00:00